What does this research mean for the field?

Hemozoin exerts a potent synergistic effect on IFN-gamma-inducible nitric oxide generation in macrophages via ERK- and NF-κB-dependent pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

October 1, 2003The Journal of ImmunologyOpen Access

Hemozoin Increases IFN-γ-Inducible Macrophage Nitric Oxide Generation Through Extracellular Signal-Regulated Kinase- and NF-κB-Dependent Pathways

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Population

B10R murine macrophages (Mphi)

Comparison

Plasmodium falciparum hemozoin and synthetic HZ… vs Untreated cells or cells treated with IFN-gamma…

Design

Preclinical

Authors

MJMaritza JaramilloInstitut National de la Recherche Scientifique DGD. Channe GowdaIndian Institute of Horticultural Research DRDanuta RadziochMcGill University Health Centre

Discussion

Member takes

Implication

May amplify macrophage NO in malaria; leaves open human immunopathology role and therapeutic targeting.

Structured PICO

Population

B10R murine macrophages (Mphi)

Intervention

Plasmodium falciparum (Pf) hemozoin (HZ) and synthetic HZ (beta-hematin), alone or in combination with IFN-gamma

Comparator

Untreated cells or cells treated with IFN-gamma alone

Outcome

Nitric oxide (NO) synthesis and inducible NO synthase (iNOS) mRNA and protein expressionsurrogate

Hemozoin exerts a potent synergistic effect on IFN-gamma-inducible NO generation in macrophages via ERK- and NF-kappaB-dependent pathways, which may contribute to malaria immunopathology.

Cite This Study

Jaramillo et al. (2003) studied this question.

synapsesocial.com/papers/6a1ee4bd5b601e8f2e04fb60 https://doi.org/10.4049/jimmunol.171.8.4243

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