Key result
Advancing age is associated with significantly decreased serum erythropoietin levels and increased vascular stiffness parameters, including pulse wave velocity and mean arterial pressure.
Why the study?
The study aimed to determine the influence of ageing on vascular health and its relation to the oxygen-sensing protein erythropoietin in both men and women.
Does ageing affect vascular stiffness parameters and serum erythropoietin levels in healthy men and women?
Cross-Sectional (n=204)
No
Does ageing affect vascular stiffness parameters and serum erythropoietin levels in healthy men and women?
p-value: p=<0.05
Ageing is associated with increased vascular stiffness and decreased serum erythropoietin levels in healthy individuals.
Age-related EPO decline may warrant monitoring in older adults; leaves open causality and therapeutic implications pending longitudinal data.
Objectives: Vascular stiffness due to ageing assessed by alteration in mean arterial blood pressure, brachial-ankle and carotid-femoral pulse wave velocity (b-f PWV/c-f PWV) and brachial and ankle arterial stiffness index (ASI). The present study aimed to determine the influence of ageing on vascular health and its relation to oxygen sensing protein that is, erythropoietin (EPO), in both genders (men and women). Materials and Methods: Randomly selected 204 healthy participants involving men and women between 20 and 95 years among the general population of city. The total sample size was split into six groups from Group I to VI, each containing 17 men participants and 17 women participants. We determined PWV [brachial-ankle and carotid-femoral (PWV)] and ASI (brachial ASI and ankle ASI) by using periscope and estimated serum erythropoietin (Epo) by ELISA method and implemented a one-way ANOVA post hoc test for statistical analysis by using SPSS software version 23. Results: Decreased serum EPO with increased vascular parameters such as mean arterial pressure (MAP), PWV and ASI observed in Group 5 and 6 of both genders. Conclusion: We conclude that ageing influences PWV, ASI, MAP and EPO in men and women participants.
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Khodnapur et al. (2021) conducted a cross-sectional in Healthy (n=204). Ageing vs. Younger age (20-29 years) was evaluated on Vascular stiffness (PWV, ASI, MAP) and serum erythropoietin (EPO) levels (p=<0.05). Advancing age is associated with significantly decreased serum erythropoietin levels and increased vascular stiffness parameters, including pulse wave velocity and mean arterial pressure.
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