Key result
Mechanical factors and the stresses of pulsation are believed to influence the localization of atherosclerotic plaques at the site of muscular cushions in peripheral arteries.
Observational
The study suggests that mechanical factors, evidenced by the development of atherosclerotic plaques at the site of muscular cushions, play a role in the localization of atherosclerosis in peripheral arteries.
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Hypothesis-generating for mechanical stress at muscular cushions; leaves open any role in peripheral artery disease prevention or management.
In a study of the peripheral arteries a period of development lasting until the end of the second decade of life is described. During this time there is evidence of medial hypertrophy and a continued formation of the longitudinal muscular cushions described in the foetus. Bands of longitudinal muscle also appear in the media of certain vessels. It is considered that the findings confirm the functional significance of foetal cushions and further suggest their relationship to the stresses of pulsation. In the later decades the tendency of atherosclerotic plaques to develop at the site of cushions is believed to reflect the importance of mechanical factors in the localization of this disease.
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J. H. Robertson (1960) conducted an observational in Atherosclerosis. Mechanical factors was evaluated on Localization of atherosclerosis. Mechanical factors and the stresses of pulsation are believed to influence the localization of atherosclerotic plaques at the site of muscular cushions in peripheral arteries.
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