Key result
Xenon inhalation anesthetic demonstrates the ability to increase myocardial resistance to ischemia and reperfusion, offering cardioprotective properties for patients at high risk of cardiac complications.
Why the study?
Does xenon inhalation anesthetic improve myocardial resistance to ischemia and reperfusion in patients at high risk of cardiac complications?
Does xenon inhalation anesthetic improve myocardial resistance to ischemia and reperfusion in patients at high risk of cardiac complications?
Xenon inhalation anesthetic shows promise for cardioprotection against ischemia and reperfusion injury through pre- and post-conditioning mechanisms.
Should not yet change anesthetic practice; leaves open xenon’s cardioprotective role pending prospective trials.
The review presents the main aspects of the cardioprotective properties of the xenon inhalation anesthetic. Based on the analysis of publications, the article discusses modern views on the mechanisms of the protective action of xenon, realized using pre- and post-conditioning mechanisms, shows major molecular targets and their effects. The article presents the results of experimental studies in vivo and in vitro, which showed the protective effect of xenon on the myocardium and the results of recent randomized clinical trials. The analysis of studies demonstrates the ability of xenon to increase myocardial resistance to ischemia and reperfusion and opens up good prospects for its use in clinical practice in patients with a high risk of cardiac complications.
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Shpichko et al. (2020) conducted a review in High risk of cardiac complications. Xenon inhalation anesthetic was evaluated. Xenon inhalation anesthetic demonstrates the ability to increase myocardial resistance to ischemia and reperfusion, offering cardioprotective properties for patients at high risk of cardiac complications.
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