Progress in Acute Myelogenous Leukemia

Editorials1 November 1984Progress in Acute Myelogenous LeukemiaROBERT PETER GALE, M.D., Ph.D.ROBERT PETER GALE, M.D., Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-101-5-702 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough leukemia is not a common disease, it has been a model for progress in modern cancer chemotherapy. Less than 30 years ago hematologists questioned whether patients with acute myelogenous leukemia should be treated (1). In the ensuing years substantial and important advances have been made, mostly within the past 10 years. Now, 60% to 80% of patients achieve a remission with intensive induction chemotherapy (1-10). Cytarabine and daunorubicin are the most effective drugs, but thioguanine, amsacrine, and high-dose cytarabine are also useful.Once remission is achieved, the next objective is to prevent leukemic relapse; this has proved difficult. Several...References1. CROSBY W. To treat or not to treat acute granulocytic leukemia. Arch Intern Med. 1968;122:79-80. CrossrefMedlineGoogle Scholar2. GALE R. Advances in the treatment of acute myelogenous leukemia. N Engl J Med. 1979;300:1189-97. CrossrefMedlineGoogle Scholar3. GALECLINE RM. High remission-induction rate in acute myeloid leukaemia. Lancet. 1977;1:497-9. CrossrefMedlineGoogle Scholar4. WEINSTEINMAYERROSENTHALCORALCAMITTAGELBER HRDFBR. Chemotherapy for acute myelogenous leukemia in children and adults: VAPA update. Blood. 1983;62:315-9. CrossrefMedlineGoogle Scholar5. YATESGLIDEWELLWIERNIK JOP. Cytosine arabinoside with daunorubicin or adriamycin for therapy of acute myelocytic leukemia: a CALGB study. Blood. 1982;60:454-62. 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ESTAPE, J.M. RODRIGUEZ FERNANDEZ, P. SANTABARBARA 1 November 1984Volume 101, Issue 5Page: 702-705KeywordsAcute myeloid leukemiaCancer chemotherapyChemotherapyDrugsHematology and oncologyThioguanine Issue Published: 1 November 1984 PDF downloadLoading ...