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Charles Bonnet Syndrome (CBS) is a complex and underrecognized condition characterized by visual hallucinations in individuals with visual impairment but preserved cognitive function. This review examines the evolving definitions, epidemiology, risk factors, and pathophysiological models of CBS. Drawing from a broad range of studies, the review identifies key diagnostic inconsistencies and highlights the syndrome's multifactorial origins, including sensory deprivation and cortical processing imbalances. Epidemiological data suggest CBS affects up to 10 % of visually impaired individuals, though prevalence estimates vary widely due to definitional discrepancies. Risk factors include low visual acuity, female sex, social isolation, and possibly certain medications, though evidence remains inconclusive. Pathophysiological theories such as deafferentation, predictive coding, and the perception-attention deficit model underscore the interplay between bottom-up and top-down mechanisms in hallucination formation. The review also explores differential diagnoses and discusses therapeutic approaches, including vision restoration, pharmacological agents, and psychoeducation. While no standardized treatment exists, early recognition and patient reassurance can significantly improve outcomes. The review calls for clearer diagnostic criteria, further research into neurobiological mechanisms, and longitudinal studies to better understand the prognosis and potential links between CBS and cognitive decline.
Christoph et al. (Fri,) studied this question.