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Synapse
December 1, 1976Proceedings of the National Academy of SciencesOpen Access

Immunological characterization of the subunit of the 100 A filaments from muscle cells.

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Population

Muscle cells (smooth muscle from chicken gizzard, skeletal muscle, and heart muscle)

Design

Preclinical

Authors

ELElias LazaridesBHB D Hubbard

Discussion

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Overview

May inform cytoskeletal research in myopathies; leaves open clinical translation from animal models.

Structured PICO

P
Population
Muscle cells (smooth muscle from chicken gizzard, skeletal muscle, and heart muscle)
I
Intervention
Isolation and immunological characterization of the 50,000 dalton subunit of 100 A intermediate filaments (desmin)
O
Outcome
Localization and characterization of the 50,000 dalton protein (desmin)

This basic science study identifies and characterizes desmin, a 50,000 dalton protein that forms intermediate filaments linking myofibrils at Z lines and intercalated disks in muscle cells.

Cite This Study

Lazarides et al. (1976) studied this question.

synapsesocial.com/papers/6a1eee2d5983aaf3a280a611https://doi.org/10.1073/pnas.73.12.4344
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