What question did this study set out to answer?

To determine whether a history of major stressful life events and prolonged mental stress are associated with arrhythmic events in patients with inherited long QT syndrome.

July 21, 2010Heart

A history of stressful life events, prolonged mental stress and arrhythmic events in inherited long QT syndrome

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Inherited long QT syndrome (LQTS) (n=1180). Intervention: Stressful life events and prolonged mental stress vs. Asymptomatic LQTS mutation carriers / non-affected relatives. Primary outcome: Arrhythmic events in LQTS mutation carriers (OR 3.40, 95% CI 1.44-8.03).

Q: What does this research mean for the field?

Prolonged mental stress and stressful life events are significantly associated with an increased risk of arrhythmic events in patients with inherited long QT syndrome. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Prolonged mental stress (OR 3.40; 95% CI 1.44-8.03) and stressful life events (OR 1.16; 95% CI 1.08-1.24) were significantly associated with arrhythmic events in patients with inherited LQTS.

Why the study?

Are stressful life events and prolonged mental stress associated with arrhythmic events in patients with inherited long QT syndrome?

Population

1,180 participants, including 566 patients with molecularly established mutation of KCNQ1, KCNH2 or SCN5A…

Comparison

History of stressful life events and prolonged… vs Asymptomatic LQTS mutation carriers and…

Design

Case-control

Authors

THTaina HintsaUniversity of Eastern Finland SPSampsa PuttonenTampere University LTL. ToivonenTampere University Hospital

Discussion

Member takes

Implication

Mental stress associated with arrhythmic events in LQTS; hypothesis-generating, requires prospective confirmation before guiding care.

Key Points

To determine whether a history of major stressful life events and prolonged mental stress are associated with arrhythmic events in patients with inherited long QT syndrome.
Evaluated 566 patients with molecularly confirmed LQT1, LQT2, or LQT3 mutations (KCNQ1, KCNH2, or SCN5A) and 614 unaffected relative controls.
Measured major stressful life events and prolonged mental stress via vital exhaustion scores from the Maastricht Questionnaire.
Performed multinomial logistic regression adjusted for age, sex, specific cardiac medications, and LQTS genetic subtype.
Compared to controls, symptomatic LQTS status was associated with stressful life events (OR=1.15, 95% CI 1.08–1.22) and vital exhaustion (OR=3.33, 95% CI 1.63–6.78) after adjusting for age and sex.
Among LQTS mutation carriers, symptomatic patients had higher exposure to stressful life events (OR=1.16, 95% CI 1.08–1.24) and over threefold higher vital exhaustion (OR=3.40, 95% CI 1.44–8.03) than asymptomatic carriers.

Study Design

Type

Case-Control (n=1,180)

Structured PICO

Are stressful life events and prolonged mental stress associated with arrhythmic events in patients with inherited long QT syndrome?

Population

1,180 participants, comprising 566 patients with molecularly established LQT1, LQT2, or LQT3 and 614 non-affected relatives.

Exposure

History of stressful life events and prolonged mental stress (vital exhaustion measured with the Maastricht Questionnaire)

Comparator

Asymptomatic LQTS mutation carriers and non-affected relatives

Outcome

Arrhythmic events (symptomatic status of LQTS)hard clinical

Main Result

Odds Ratio: 3.4 (95% CI 1.44–8.03)

A history of stressful life events and prolonged mental stress are significantly associated with a higher risk of arrhythmic events in patients with inherited long QT syndrome.

Cite This Study

Hintsa et al. (2010) conducted a case-control in Inherited long QT syndrome (LQTS) (n=1,180). Stressful life events and prolonged mental stress vs. Asymptomatic LQTS mutation carriers / non-affected relatives was evaluated on Arrhythmic events in LQTS mutation carriers (OR 3.40, 95% CI 1.44-8.03). Prolonged mental stress (OR 3.40; 95% CI 1.44-8.03) and stressful life events (OR 1.16; 95% CI 1.08-1.24) were significantly associated with arrhythmic events in patients with inherited LQTS.

synapsesocial.com/papers/6a1eef2586a165c8f0972113 https://doi.org/10.1136/hrt.2009.190868

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A history of stressful life events, prolonged mental stress and arrhythmic events in inherited long QT syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

A history of stressful life events, prolonged mental stress and arrhythmic events in inherited long QT syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider