Key result
W-7 selectively inhibits insulin stimulation of glucose transport, causing a fivefold increase in the insulin concentration needed for half-maximal stimulation (from ~70 to ~350 microU/ml, P<0.05).
Population
Skeletal muscle
Comparison
W-7 (50 microM) combined with insulin or hypoxia vs Maximal or submaximal insulin or hypoxia alone
Design
Preclinical
Authors
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Should not guide clinical insulin management; leaves open calmodulin's mechanistic role in skeletal muscle glucose transport.
p-value: p=< 0.05
W-7 selectively inhibits insulin stimulation of glucose transport in skeletal muscle, while acting additively with hypoxia.
Youn et al. (1994) studied this question. W-7 vs. Insulin and hypoxia was evaluated on 3-O-methylglucose (3-MG) transport (p=< 0.05). W-7 selectively inhibits insulin stimulation of glucose transport, causing a fivefold increase in the insulin concentration needed for half-maximal stimulation (from ~70 to ~350 microU/ml, P<0.05).