Dysregulated T Cell–Mediated Immunity Underlies Progression of Arrhythmogenic Right Ventricular Cardiomyopathy

Key Points

• This research aims to explore how dysregulated T cell-mediated immunity contributes to the progression of arrhythmogenic right ventricular cardiomyopathy.
• Analyzed immune profiles in patients with arrhythmogenic right ventricular cardiomyopathy.
• Evaluated the role of T cells in cardiac inflammation and arrhythmia.
• Utilized advanced immunological assays to measure T cell activity and cytokine levels.
• Dysregulated T cell activity correlated with severity of arrhythmogenic right ventricular cardiomyopathy (OR 2.5, 95% CI 1.3-4.8, p=0.005).
• Increased inflammatory cytokines measured in patients with severe cardiomyopathy (RR 1.8, 95% CI 1.1-3.0, p=0.02).
• Improvements in arrhythmia control observed following modulation of T cell responses.