Key result
Physiologic stimulation of carotid chemoreceptors with hypoxic and hypercapnic blood produced vasoconstriction in the muscle and vasodilatation in the paw in anesthetized dogs.
Why the study?
Does physiologic stimulation of carotid chemoreceptors produce different responses in blood vessels of skin and muscle in anesthetized dogs?
Does physiologic stimulation of carotid chemoreceptors produce different responses in blood vessels of skin and muscle in anesthetized dogs?
Physiologic stimulation of carotid chemoreceptors produces contrasting responses in different vascular beds, specifically vasoconstriction in muscle and vasodilatation in skin.
Should not inform human care; leaves open generalizability of differential muscle-skin vascular responses to chemoreceptor stimulation.
Experiments were performed to determine whether physiologic stimulation of carotid chemoreceptors produces different responses in blood vessels of skin and muscle. Carotid chemoreceptors of anesthetized dogs were stimulated with hypoxic and hypercapnic blood and responses were observed in the isolated, perfused gracilis muscle and hindpaw. Chemoreceptor stimulation produced vasoconstriction in the muscle and vadodilatation in the paw (a predominantly cutaneous vascular bed). Responses to hypoxia without hypercapnic acidosis tended to be less pronounced. The study indicates that physiologic stimulation of carotid chemoreceptors produces contrasting responses in different vascular beds.
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Heistad et al. (1975) studied this question. Physiologic stimulation of carotid chemoreceptors with hypoxic and hypercapnic blood vs. Hypoxia without hypercapnic acidosis was evaluated on Vascular response in muscle and paw. Physiologic stimulation of carotid chemoreceptors with hypoxic and hypercapnic blood produced vasoconstriction in the muscle and vasodilatation in the paw in anesthetized dogs.