Rabbit antisera against red blood cells from three‐day‐old chickens, absorbed with adult chicken red blood cells, identify an antigen on the red blood cells of young chickens that is not detectable in adults. The antigen is present on all red blood cells at hatching. Approximately 50 days after hatching, cells with the antigen start to disappear and are completely undetectable by 120 days. Studies aimed at elucidating the mechanism of the developmental antigenic change suggested that the antigen or a component of the antigen is lost during development rather than being coated by a serum component or embedded in the red blood cell membrane. Various experiments were performed in an attempt to alter the proportion of cells carrying the antigen.
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Bob G. Sanders (1968) studied this question.
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