Key result
Family history and chronic illnesses predicted the onset of major depression within 1 year among 109 primary care patients with subthreshold depression, of whom 20 developed the condition.
Why the study?
What factors predict the onset of major depression in primary care patients with subthreshold depression?
Cohort (n=109)
What factors predict the onset of major depression in primary care patients with subthreshold depression?
Family history and chronic illnesses are significant predictors for the development of major depression within one year in primary care patients with subthreshold depression.
May aid risk stratification in primary care; hypothesis-generating and leaves open whether interventions prevent progression.
OBJECTIVE: That subjects with subthreshold depression have an increased probability of developing major depression has been confirmed by many studies. However, the factors which may predict the onset of major depression have yet to be fully examined. METHOD: We examined the control group of a randomized trial in primary care patients with subthreshold depression (N = 109), of whom 20 had developed major depression 1 year later. Using the vulnerability-stress theory, we examined which factors predicted the onset of major depression. RESULTS: In both univariate and multivariate analyses, family history and chronic illnesses predicted the onset of major depression. CONCLUSION: It is possible to predict to a certain degree whether a subject with subthreshold depression will develop major depression within a year.
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Cuijpers et al. (2004) conducted a cohort in Subthreshold depression (n=109). Family history and chronic illnesses was evaluated on Onset of major depression. Family history and chronic illnesses predicted the onset of major depression within 1 year among 109 primary care patients with subthreshold depression, of whom 20 developed the condition.
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