Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine

Q: What does this research mean for the field?

The potential bioactivation and genotoxicity liabilities of the N-nitroso derivative of paroxetine highlight the need for further scrutiny and additional examples to bolster structure-genotoxicity relationships of complex N-nitrosamine drug substance-related impurities (NDSRIs). Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Carley J. S. Heck; Heather Eng; Jennifer Cheung; Joseph Tillotson; Krista L. Dobo; Amit S. Kalgutkar

doi:10.1080/00498254.2025.2586614

November 6, 2025XenobioticaOpen Access

Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine

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Abstract

needs to be scrutinised further with additional examples to bolster structure-genotoxicity relationships of complex NDSRIs.

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Heck et al. (2025) studied this question.

synapsesocial.com/papers/6a1f13e2b7011e5ec239dcba https://doi.org/10.1080/00498254.2025.2586614

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Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine

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Studies addressing potential bioactivation and genotoxicity liabilities of the N -nitroso derivative of the antidepressant paroxetine

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