Key result
Obesity impacts the viral response and COVID-19 prognosis through changes in the immune response, nutritional factors, physiological factors, and the gut-lung axis.
Why the study?
Obesity has emerged as a risk factor associated with COVID-19 disease severity amidst the rising worldwide incidence of obesity.
How does obesity impact the viral response and prognosis in patients with COVID-19?
How does obesity impact the viral response and prognosis in patients with COVID-19?
Obesity is a major risk factor for severe COVID-19, with its impact mediated by multiple physiological and immunological mechanisms.
Answers are grounded in this paper and cite their sources.
Obesity may worsen COVID-19 prognosis via immune and physiological pathways; leaves open mechanistic targets for prospective trials.
The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for health-care systems worldwide. Many different risk factors are associated with disease severity, such as older age, diabetes, hypertension, and most recently obesity. The incidence of obesity has been on the rise for the past 25 years, reaching over 2 billion people throughout the world, and obesity itself could be considered a pandemic. In this review, we summarize aspects involved with obesity, such as changes in the immune response, nutritional factors, physiological factors, and the gut-lung axis, that impact the viral response and the COVID-19 prognosis.
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Alberca et al. (2020) conducted a review in COVID-19. Obesity was evaluated. Obesity impacts the viral response and COVID-19 prognosis through changes in the immune response, nutritional factors, physiological factors, and the gut-lung axis.
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