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Abstract The present studies show that human platelets can incorporate uniformly labeled 14C-l-leucine into trichloracetic acid-precipitable material. This material is digested by Pronase but not by deoxyribonuclease or ribonuclease. Acid hydrolysis of the material liberates a compound with chromatographic properties identical with those of authentic l-leucine. The incorporation of uniformly labeled 14C-l-leucine by platelets is inhibited by puromycin but not by actinomycin D. To our knowledge, this study constitutes the first definite demonstration that mammalian platelets can synthesize protein.
Warshaw et al. (Mon,) studied this question.
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