From the original PREFACE: The rings of quotients recently introduced by Johnson and Utumi are applied to the ring $C(X)$ of all continuous real-valued functions on a completely regular space X. Let $Q(X)$ denote the maximal ring of quotients of $C(X)$; then $Q(X)$ may be realized as the ring of all continuous functions on the dense open sets of X (modulo an obvious equivalence relation). In special cases (e.g., for metric X), $Q(X)$ reduces to the classical ring of quotients of $C(X)$ (formed with respect to the regular elements), but in general, the classical ring is only a proper sub-ring of $Q(X)$.
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Fine et al. (2024) studied this question.