Despite this initial controversial finding, the subsequent obesity GWAS have been extremely successful. Common variants at two loci, fat mass and obesity associated gene (FTO) [11, 12] Both variants together explain approximately 0.5% of the BMI variance. The three novel studies analyzed more than 150,000 (!) individuals in total for genetic variants relevant in body weight regulation: -One GWAS was performed with 305,846 SNPs typed in 25,344 Icelandic, 2,998 Dutch, 1,890 European American and 1,160 African American subjects and combined with results previously published by the Diabetes Genetics Initiative (DGI) based on 3,024 Scandinavians. 43 variants in 19 regions were selected for follow-up in 5,586 Danish individuals. The results were compared with the results of the obesity GWAS of the GIANT consortium [2] (see below).
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Hinney et al. (2009) studied this question.
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