Key result
Extracorporeal membrane oxygenation circuits activate the coagulation system, platelets, leucocytes, and complement, leading to high rates of both thrombosis and hemorrhage.
Design
Review
Authors
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Supports heightened vigilance for dual hemostatic risks in ECMO; leaves open optimal mitigation strategies.
ECMO circuits induce complex hemostatic changes including coagulation activation, platelet dysfunction, and acquired von Willebrand syndrome, leading to concurrent risks of thrombosis and hemorrhage.
Doyle et al. (2018) conducted a review in Severe respiratory and cardiac failure requiring ECMO. Extracorporeal Membrane Oxygenation (ECMO) was evaluated. Extracorporeal membrane oxygenation circuits activate the coagulation system, platelets, leucocytes, and complement, leading to high rates of both thrombosis and hemorrhage.
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