Key result
A method and experimental defibrillator were developed for dynamic pulse duration adjustment to obtain a desired optimal time-course of the cardiac cell transmembrane potential.
The development of an experimental defibrillator capable of dynamic pulse duration adjustment based on transthoracic resistance may optimize the time-course of cardiac cell transmembrane potential during defibrillation.
Hypothesis-generating for adaptive defibrillation; clinical trials needed before any practice consideration.
Many studies have proven that biphasic defibrillation pulses are more efficient than the damped sinusoid monopolar waveform. Transthoracic resistance was shown to change during the two phases. On the other hand, it was proven that transthoracic resistance plays an important role in the defibrillation process, yielding the current for selected energy or voltage. Pre-shock measurement of the resistance may lead to improved selection. Stabilized current defibrillators are of low stored-to-delivered energy ratio. Therefore, automatic dynamic adjustment of some defibrillator parameters with respect to transthoracic resistance changes seems rational. An approach is known for modifying the pulse duration, in order to deliver a selected energy. A method is proposed here and an experimental defibrillator is developed for dynamic pulse duration adjustment with the purpose of obtaining a desired optimal time-course of the cardiac cell transmembrane potential.
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Vessela Krasteva (2000) studied Defibrillation. Automatic dynamic adjustment of biphasic pulse duration was evaluated on Optimal time-course of the cardiac cell transmembrane potential. A method and experimental defibrillator were developed for dynamic pulse duration adjustment to obtain a desired optimal time-course of the cardiac cell transmembrane potential.
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