Underweight status was associated with a significantly higher risk of all-cause mortality (HR 2.729) compared to obesity class II in patients with acute heart failure.
Cohort (n=4,146)
Sí
Does lower BMI or lower muscle mass increase the risk of all-cause mortality in patients with acute heart failure?
Lower BMI and reduced muscle mass are independently associated with higher all-cause mortality in patients with acute heart failure, supporting the obesity paradox across various HF phenotypes.
Hazard Ratio: 2.729 (95% CI 1.686–4.417)
Tasa de eventos absoluta: 61.7% vs 26%
valor p: p=<0.001
Background and Objectives: Lower body mass index (BMI) is considered a poor prognostic factor in patients with heart failure (HF). We aimed to investigate the clinical impact of BMI on the risk of mortality in patients with acute HF (AHF) across various phenotypes. Methods: (obesity II; n=233). The risk of all-cause mortality was compared between these 5 groups. Results: ), calculated using serum cystatin C data in a subset of 579 patients, was associated with higher mortality risk. Conclusions: A lower BMI is associated with a higher risk of mortality in patients with AHF. This obesity paradox is observed in AHF regardless of comorbidities and HF phenotype.
Hwang et al. (Sat,) conducted a cohort in Acute Heart Failure (n=4,146). Lower Body Mass Index (Underweight) vs. Obesity class II (BMI ≥30 kg/m2) was evaluated on All-cause mortality (HR 2.729, 95% CI 1.686-4.417, p=<0.001). Underweight status was associated with a significantly higher risk of all-cause mortality (HR 2.729) compared to obesity class II in patients with acute heart failure.