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The therapeutic efficacy of many established sulfur-containing medications may be partially mediated by the release of hydrogen sulfide (H2S) during drug metabolism or through their effects on endogenous H2S production. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 18, 2020Biomolecules132 citationsOpen Access

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

EZEwelina ZaorskaUniversity of Warsaw LTLenka TomášováInstitute of Chemistry of the Slovak Academy of Sciences DKDominik KoszelewskiInstitute of Organic Chemistry

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Abstract

Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early clinical studies. For example, H2S donors have been found to be effective in the prevention of gastrointestinal ulcers during anti-inflammatory treatment. Notably, there are well-established medicines used for the treatment of a variety of diseases, whose chemical structure contains sulfur moieties and may release H2S. Hence, the therapeutic effect of these drugs may be partly the result of the release of H2S occurring during drug metabolism and/or the effect of these drugs on the production of endogenous hydrogen sulfide. In this work, we review data regarding sulfur drugs commonly used in clinical practice that can support the hypothesis about H2S-dependent pharmacotherapeutic effects of these drugs.

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