Ten-Year Follow-up of Cluster-based Asthma Phenotypes in Adults. A Pooled Analysis of Three Cohorts

Key Points

To examine the stability and transitions of cluster-based asthma phenotypes in adults over a decade.
Applied latent transition analysis on data from 3,320 adults with asthma, measured twice 10 years apart.
Considered nine variables related to personal and phenotypic characteristics.
Identified seven distinct asthma phenotypes with prevalence from 8.4% to 20.8%.
Probabilities of remaining in the same phenotype ranged from 54% to 88% after ten years.
Observed greater transitions to worsened symptoms in nonallergic phenotypes compared to allergic ones.

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Compares asthma phenotype stability in adults over ten years, suggesting strong consistency in classifications.

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Boudier et al. (2013) studied this question.

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