Why the study?
Do antioxidants and methionine alter the effects of platelet-activating factor on cardiovascular function and oxidative stress markers in anesthetized dogs?
Do antioxidants and methionine alter the effects of platelet-activating factor on cardiovascular function and oxidative stress markers in anesthetized dogs?
No data provided; leaves open whether antioxidants or methionine alter PAF effects on canine cardiovascular function.
Platelet-activating factor (PAF) is released in numerous clinical situations. PAF primes or directly activates polymorphonuclear (PMN) leukocytes, which results in release of oxyradicals (O− 2, H2O2, .OH) and hypochlorous acid (HOCl). The authors investigated the effects of PAF (1 μg/kg IV) in the absence and in the presence of antioxidants (superoxide dismutase [SOD], catalase [CAT], dimethylthiourea [DMTU]) and methionine, a quencher of HOCl, on cardiac function and contractility; blood lactate, gases, and pH levels; serum creatine kinase activity (CK); chemiluminescent activity of PMN leukocytes; and cardiac tissue malondialdehyde (MDA) in anesthetized dogs. Hemodynamic measurements and collection of blood samples for various biochemical measurements were made before and at various intervals up to two hours after PAF administration in the presence and absence of various antioxidants.
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Prasad et al. (2005) studied this question.
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