Long‐Chain Lipids Are Required for the Innate Immune Recognition of Trehalose Diesters by Macrophages

Going to any length? Trehalose diesters of various chain lengths have been synthesised in order to determine the effect of lipid length on innate immune recognition, as determined by NO (see graph) and cytokine production by macrophages. In this work, we show that longer lipids (C20–C26) are required for macrophage activation, with C22 giving optimal activity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.