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In the mid nineteenth century the first case of multiple myeloma (MM) was reported by Henry Bence Jones (1847) and William MacIntyre (1850). The patient, Mr Thomas Alexander McBean, complained of chest and back pain, fatigue and urinary frequency. His urine was said to contain the oxide of albumin and at post-mortem his bones were found to be soft and filled with a gelatinous material. This condition of bone softening was designated 'mollities ossium' by Dalrymple in 1846; while the term multiple myeloma was introduced some years later by Von Rustisky (1873).
Owen et al. (Sat,) studied this question.