The appearance of increased quantities of ESF in the sera of rats following androgen administration or exposure to hy-poxia has been related to increased amounts or activity of the renal erythropoietic factor (REF). Plethora induced in rats by hyper-transfusion results in a marked decrease in REF activity in response to androgen or hypoxia. This is proposed as the mechanism by which plethora inhibits the production of ESF.
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Gordon et al. (1966) studied this question.