In this contribution, we report the formation under prebiotic conditions of phosphoribosyl pyrophosphate (PRPP) as a molecular precursor in the one‐pot synthesis of a canonical nucleotide, namely adenosine monophosphate (AMP) from its building blocks (KH 2 PO 4 or P i , adenine, and d ‐ribose), on a fumed silica surface. The on‐the‐rocks approach has been successfully applied to the simultaneous phosphorylation and glycosylation of ribose. The one‐pot formation mechanism of AMP involves a two‐step pathway via an activated intermediate, namely PRPP, obtained by multiple ribose phosphorylations upon mild thermal activation.
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Akouche et al. (2017) studied this question.
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