Masked hypertension in young adults was associated with higher odds of increased left ventricular mass index (OR 1.67, P=0.031) compared to normotensive individuals.
Cross-Sectional (n=774)
Does masked hypertension associate with increased left ventricular mass index and altered left ventricular function in young healthy adults?
Masked hypertension in young, apparently healthy adults is independently associated with increased left ventricular mass index, indicating early target organ damage and increased risk for future cardiovascular disease.
Odds Ratio: 1.67
p-value: p=0.031
OBJECTIVE: Masked hypertension is reportedly common in young adults. However, it is unknown if these masked hypertensive individuals already present with organ damage. We determined whether a relationship exists between left ventricular structure and function, and masked hypertension in young healthy adults. METHODS: In this cross-sectional study, we included 774 black and white men and women (aged 20-30 years) who had successful ambulatory blood pressure monitoring readings (>70% valid readings) and valid echocardiography done. RESULTS: We found that 16.4% had masked hypertension (60.6% whites; 67.7% men). When performing multivariable-adjusted logistic regression, we found masked hypertensive patients to have higher odds to present with increased left ventricular mass index (odds ratio 1.67, P = 0.031) compared to normotensive individuals. In multivariable-adjusted linear regression analyses, left ventricular mass index positively and independently associated with masked hypertension adjusted R = 0.193, β = 0.08 (0.01; 0.16), P = 0.046. However, we found no independent link between echocardiographic measures of left ventricular function and masked hypertension. CONCLUSION: This study highlights the importance of the early detection of masked hypertension as young apparently healthy adults already show an increased left ventricular mass index, thereby indicating increased risk for future cardiovascular disease.
Sekoba et al. (Thu,) conducted a cross-sectional in Masked hypertension (n=774). Masked hypertension vs. Normotensive individuals was evaluated on Increased left ventricular mass index (OR 1.67, p=0.031). Masked hypertension in young adults was associated with higher odds of increased left ventricular mass index (OR 1.67, P=0.031) compared to normotensive individuals.