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The endothelial glycocalyx (EG) is widely located on the surface of endothelial cell membrane. It serves as an important component of the endothelial cell barrier and plays a crucial role in maintaining charge balance within the cell. The shedding, excessive thickening and deposition of the EG located on the surface of endothelial cells within the renal capillary network is widely observed in acute kidney injury and chronic kidney disease. Based on recent research advancements, this article focuses on how the EG in the renal microvasculature participates in pathological processes such as renal tubulointerstitial fibrosis, cross-talk between endothelial cells and epithelial cells, and immune system dysregulation. Preserving and restoring the integrity of the EG in the renal microvasculature has emerged as an innovative strategy for the early prevention and treatment of kidney diseases. This includes supplementation of EG components and inhibition of EG shedding ingredients to prevent EG damage.
Yuan et al. (Tue,) studied this question.
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