A log-adjusted t-statistic for large clinical laboratory datasets: a simulation study and real-world application

Key Points

• This research aims to assess the utility of the log-adjusted t-statistic for large clinical laboratory datasets.
• Simulation study focusing on large datasets
• Evaluation of significance thresholds
• Application in real-world clinical data
• Log-adjusted t-statistic aids in interpreting significance without being driven solely by sample size.
• Preserves the ability to detect meaningful effects despite larger samples.