RNF145 promotes inflammation in recurrent spontaneous abortion through inducing the K63-linked polyubiquitination of IRF3

Q: What does this research mean for the field?

RNF145 promotes inflammation and interferon-I responses in recurrent spontaneous abortion by interacting with IRF3 and inducing its K63-linked polyubiquitination. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Yuqin Chen; Lin Zheng; Haiyan Gao; Xiaoqing Wu; Shuqiong He; Qingmei Shen; Xiali Jiang; H G Huang; R Zhang; Liangpu Xu

doi:10.1016/j.jri.2026.104919

June 1, 2026Journal of Reproductive ImmunologyOpen Access

RNF145 promotes inflammation in recurrent spontaneous abortion through inducing the K63-linked polyubiquitination of IRF3

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to understand how RNF145 influences inflammation in recurrent spontaneous abortion (RSA) by examining its interaction with IRF3.
Analyzed levels of IFN-Is and inflammatory cytokines in relation to RNF145 expression in RSA.
Investigated the interaction between RNF145 and IRF3 in signaling pathways.
Examined the mechanisms by which RNF145 induces K63-linked ubiquitination of IRF3.
RNF145 levels are significantly higher in RSA cases, correlating with increased IFN-I and inflammatory cytokine levels.
RNF145 enhances IRF3-dependent signaling, suggesting a direct role in promoting inflammation.
K63-linked ubiquitination of IRF3 by RNF145 was confirmed, implicating it in RSA inflammation.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Shows RNF145 promotes inflammation in recurrent spontaneous abortion, highlighting its role in immune response regulation.

Abstract

• IFN-Is and inflammatory cytokines are upregulated in RSA, as well as RNF145. • RNF145 promotes IFN-I and inflammatory responses in RSA by enhancing IRF3-dependent signalling. • RNF145 interacts with IRF3 and induces its K63-linked ubiquitination.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc47adee9eb8c0dce5f41 https://doi.org/10.1016/j.jri.2026.104919

View Full Paper

Ask AI

Bookmark

Share

RNF145 promotes inflammation in recurrent spontaneous abortion through inducing the K63-linked polyubiquitination of IRF3

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

RNF145 promotes inflammation in recurrent spontaneous abortion through inducing the K63-linked polyubiquitination of IRF3

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading