Lactiplantibacillus plantarum KLDS1.0344 ameliorates depressive-like behavior in CUMS mice: integrative multi-omics evidence linking gut microbiota alterations to sphingolipid and glycerophospholipid metabolic pathways

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Key Points

This research aims to explore how Lactiplantibacillus plantarum KLDS1.0344 affects depressive-like behavior in mice through metabolic pathways.
Mice were subjected to chronic unpredictable mild stress (CUMS) for behavioral assessment.
Multi-omics analysis was performed to investigate gut microbiota and metabolic pathways related to sphingolipid and glycerophospholipid metabolism.
The effect of Lactiplantibacillus plantarum KLDS1.0344 was evaluated in comparison to control groups.
Lactiplantibacillus plantarum KLDS1.0344 administration significantly decreased depressive-like behavior in CUMS mice, as indicated by behavioral tests.
Alterations in gut microbiota composition linked to improvements in sphingolipid and glycerophospholipid pathways were observed, suggesting a mechanistic role in mood regulation.
Specific metabolomic changes correlated with reduced depressive symptoms in treated mice.

Shows Lactiplantibacillus plantarum reduces depressive-like behavior in mice, indicating its potential therapeutic benefits.

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Dou et al. (2026) studied this question.

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