This study explores the potential of the triglyceride-to-high-density lipoprotein-cholesterol (TG/HDL-C) ratio and the triglyceride-glucose (TyG) index as alternative markers of glycaemic control in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Conducted on 91 adults with T2DM and CKD, data were obtained from fasting lipid profile, fasting plasma glucose (FPG), serum creatinine, and HbA1c levels. Statistical analysis demonstrated a strong positive correlation between HbA1c levels and both the TG/HDL-C ratio (r = 0.570) and the TyG index (r = 0.729), with both associations reaching a high level of statistical significance (p <0.001). The TyG index also remained independently significant in linear regression analysis. These observations highlight the potential of the TG/HDL-C ratio and the TyG index as effective, low-cost, and accessible surrogate markers for glycaemic control, especially valuable in low-resource settings where HbA1c testing may be limited. Both indices could help mitigate the risk of diabetic complications, especially cardiovascular disease, among individuals with CKD. Key Words: Triglyceride/high-density lipoprotein ratio, Triglyceride glucose index, HbA1c, Chronic kidney disease, Cardiovascular disease.
Iftikhar et al. (Mon,) studied this question.