Effects of electroacupuncture at Yanglingquan （GB 34） and Huantiao （GB 30） acupoints with different frequencies on pain behaviors and analgesic mechanisms in rats with neuropathic pain

May 1, 2026Lishizhen medicine and materia medica research

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Key Points

This study aims to investigate the effects of electroacupuncture at specific acupoints on pain behaviors and associated protein levels in a neuropathic pain rat model.
54 SD rats were randomly assigned to groups: normal, model, placebo, and three electroacupuncture frequency groups (2Hz, 50Hz, 100Hz), with 9 rats per group.
Chronic constriction injury (CCI) was induced in all but the normal group; electroacupuncture was applied for 30 minutes daily over 7 days.
Measurements included mechanical and thermal pain thresholds, serum cytokine levels via ELISA, and protein and mRNA expression via Western blot and PCR.
Compared to the normal group, the model group showed significantly decreased pain thresholds (P<0.001) and increased inflammatory cytokines (P<0.05, P<0.01).
Electroacupuncture at 2Hz and 50Hz significantly improved pain thresholds (P<0.001, P<0.01) and reduced inflammatory cytokines (P<0.05, P<0.01) compared to the model group.
The 2Hz group showed increased CB1R expression and decreased NR2B, ERK5 expression (P<0.01), implicating it as the optimal treatment frequency.

Examines how different frequencies of electroacupuncture reduce pain in rats, suggesting optimal treatment frequency.

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LE et al. (2026) studied this question.

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