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June 3, 2026Science of Traditional Chinese MedicineOpen Access

Chemical profiling and anti-inflammatory mechanism of modified Buyang Huanwu Decoction in treating cerebral ischemic stroke

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Authors

YKYanan KangZWZi WangYXYicen Xu

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Overview

Randomized trial demonstrates neuroinflammatory benefits of modified Buyang Huanwu Decoction for cerebral ischemic stroke, suggesting a new therapeutic approach.

Key Points

  • This research aims to examine the chemical constituents and anti-inflammatory mechanisms of modified Buyang Huanwu Decoction in treating cerebral ischemic stroke.
  • Utilized UPLC-Q-TOF/MS E for chemical analysis of MBYHW.
  • Conducted metabolic studies on rat plasma after oral administration.
  • Employed network pharmacology and cellular models to assess anti-inflammatory effects.
  • Identified 190 compounds in vitro and 33 prototype components in plasma.
  • Confirmed 5 active components that inhibited pro-inflammatory factors in BV-2 cells.
  • Demonstrated MBYHW Decoction enhanced neurological outcomes in MCAO rat models.

Cite This Study

Kang et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc4e4dee9eb8c0dce6558https://doi.org/10.1097/st9.0000000000000126
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elucidating the mechanism of Buyang Huanwu Decoction in the treatment of ischemic stroke: A network pharmacology and molecular docking study2026
  2. 2UPLC-MS based metabonomics revealed the protective effects of Buyang Huanwu decoction on ischemic stroke rats2024 · 4 citations
  3. 3Molecular Mechanisms and Clinical Applications of Buyang Huanwu Decoction in the Treatment of Ischemic Stroke: A Review2026
  4. 4Neuroprotective mechanisms of Buyang Huanwu decoction in ischemic stroke2025 · 5 citations
  5. 5A meta-analysis of the efficacy of Buyang Huanwu decoction in the treatment of ischemic stroke2024 · 1 citations