PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
June 3, 2026Human Molecular Genetics0 citations

Combined GWAS Identifies LINC01541 as Regulator of Innate Immunity

Combined periodontitis GWAS identifies LINC01541 as a regulator of innate immunity in the oral mucosa

View Full Paper
Ask AI
Bookmark
Share

Authors

GRG. RichterOAOluwabukunmi M AkinloyeTKTim Kühnlenz

Discussion

Loading...

Member takes

Overview

Randomized trial reveals LINC01541's role in modulating immune responses in periodontitis, indicating its potential therapeutic relevance.

Key Points

  • This research aims to identify genetic factors shared between early- and later-onset periodontitis and the role of LINC01541 in immune regulation.
  • Combined two European GWAS datasets of periodontitis (N=3183 cases, 10326 controls)
  • Applied Fisher’s combined probability test and GWAMA across >7 million variants
  • Evaluated LINC01541 function via CRISPR interference in gingival fibroblasts.
  • Identified LINC01541 with strong genetic signal (rs11876034, P = 1.7 × 10−6)
  • LINC01541 knockdown resulted in significant downregulation of inflammatory mediators (e.g., CSF2, IL1B)
  • Gene-set enrichment showed repression of cytokine signaling and activation of cell-cycle pathways.

Cite This Study

Richter et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc4e4dee9eb8c0dce6666https://doi.org/10.1093/hmg/ddag039
View Full Paper
Ask AI
Bookmark
Share