Morin significantly attenuated myocardial injury in experimental autoimmune myocarditis by reducing lipid peroxidation, lowering serum CK-MB and LDH, and preserving myocardial architecture.
Does Morin mitigate immune-mediated myocardial injury in male BALB/c mice with experimental autoimmune myocarditis?
Morin demonstrates significant cardioprotective effects in a murine model of experimental autoimmune myocarditis by reducing oxidative stress and preserving cardiac structure.
Objective: To evaluate the cardioprotective effects of Morin in experimental autoimmune myocarditis by assessing its influence on immune-mediated myocardial injury, oxidative stress, and cardiac structural damage, and to explore its therapeutic potential in autoimmune cardiac disease.Design and method: Experimental autoimmune myocarditis was induced in male BALB/c mice using cardiac porcine myosin emulsified in Freund's complete adjuvant on day 1 and 8 subcutaneously. Morin was administered orally at doses of 40 mg/kg and 80 mg/kg from Day 9 to Day 35 following immunization. Disease severity was assessed through estimation of oxidative stress markers (malondialdehyde, glutathione, superoxide dismutase, nitric oxide) in cardiac tissue, serum cardiac injury markers (CK-MB and LDH), and histopathological evaluation of myocardial tissue using H&E staining. Statistical analysis was performed using one-way ANOVA with Bonferroni post-hoc testing. Results: Autoimmune myocarditis resulted in severe myocardial inflammation, elevated oxidative stress, increased cardiac injury markers, and extensive histopathological damage with inflammatory cell infiltration and myocyte loss. Morin treatment significantly attenuated myocardial injury, demonstrated by reduced lipid peroxidation, lower serum CK-MB and LDH levels, and marked preservation of myocardial architecture with reduced inflammatory infiltrates. Dose-dependent differences were observed, with Morin-treated groups showing distinct biochemical and structural improvements compared to disease controls. Conclusions: Morin confers significant cardioprotection in experimental autoimmune myocarditis by mitigating immune-mediated myocardial injury, reducing oxidative stress, and preserving cardiac structure. These findings highlight Morin as a promising multi-target therapeutic candidate for autoimmune-mediated cardiac disorders and support further translational investigations.
Kumaraguruparan et al. (Fri,) conducted a other in Experimental autoimmune myocarditis. Morin vs. Disease controls was evaluated on Myocardial injury, oxidative stress, and cardiac structural damage. Morin significantly attenuated myocardial injury in experimental autoimmune myocarditis by reducing lipid peroxidation, lowering serum CK-MB and LDH, and preserving myocardial architecture.
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