What is the clinical evidence from this study?

Study design: Observational. Population: Hypertension (n=62194). Intervention: Antihypertensive treatment. Primary outcome: Uncontrolled hypertension based on 24-hour ABPM values.

What does this research mean for the field?

In real-world practice in Hungary, a high proportion of hypertensive patients receive monotherapy contrary to current guidelines, resulting in high rates of uncontrolled blood pressure that are further exacerbated by lifestyle risk factors. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

The aim is to analyze antihypertensive drug consumption and blood pressure control rates in Hungarian patients with hypertension.

June 3, 2026

Antihypertensive Drug Consumption Habits and Blood Pressure Control Rate in Hungary Based on the Abpm Registry

Resultado clave

Among treated hypertensive patients in the Hungarian ABPM Registry, 64.1% had uncontrolled 24-hour blood pressure, with smoking, obesity, coffee consumption, and snoring increasing this risk.

Puntos clave

The aim is to analyze antihypertensive drug consumption and blood pressure control rates in Hungarian patients with hypertension.
Data collected from the Hungarian ABPM Registry, an ongoing multicenter observational study.
Included 62,194 adult patients with known or suspected hypertension.
Analyzed medication patterns and blood pressure control using 24-hour ABPM values.
71.1% of patients received antihypertensive treatment; 64.1% had uncontrolled hypertension based on 24-hour ABPM.
43.2% received monotherapy, while 37.1% and 19.7% received dual and triple combination therapies, respectively.
Lifestyle risk factors like smoking and obesity significantly increased the risk of uncontrolled hypertension.

Diseño del estudio

Tipo

Observational (n=62,194)

Enmascaramiento

Open-label

Multicéntrico

Sí

PICO estructurado

Población

62,194 adult patients with known or suspected hypertension in Hungary, assessed for antihypertensive medication habits and blood pressure control.

Exposición

Antihypertensive treatment (monotherapy, dual combination therapy, or triple combination therapy)

Resultado

Medication taking habits and blood pressure control ratesurrogate

A large Hungarian registry reveals that a high proportion of treated hypertensive patients remain on monotherapy and have uncontrolled blood pressure, highlighting a gap between current guidelines and clinical practice.

Resumen

Objective: Current ESH Guidelines recommend first-line combination therapy and up-titration of antihypertensive drugs to reach target blood pressure (BP). Thus we aimed to analyse medication taking habits and BP control rate according to the Hungarian ABPM Registry. Design and method: Data were collected from the Hungarian ABPM Registry, which is an ongoing, multicenter, open-label, observational study. Adult patients (n=62,194, age: 55.15±15.18 years, female: 54.5%) with known or suspected hypertension (HT) were included in the study. Validated Meditech ABPM-06 was used. Data collected between 01.03.2021-17.11.2025. were analyzed in this report. Results: 71.1%(n=44,205) of all patients received antihypertensive treatment, of whom a total of 39,734 treated people (63.8%) were analysed due to lack of data. 17,197 patients (43.2%) received monotherapy (MT), 14,732 patients (37.1%) received dual combination therapy (DCT) and 7,805(19.7%) received triple combination therapy (TCT). 12.5%(n=4,959) of the treated patients received a TCT that included thiazide or thiazide-like diuretic component (THZD). Among the DCT group 94.9% (n=13,981) and among the TCT group 99.7%(n=7,787) received a RAAS blocker (ACE-inhibitor or ARB). The second most frequent component of the DCT was calcium channel blocker (CCB)(38.1%, n=5,612), and the third was beta-blocker (BBL)(30.0%, n=4,419). In the TCT group, in addition to the RAAS blocker, the most frequently used drugs were CCB(66.3%, n=5,177), then BBL(53.0%, n=4,136), indapamide(40.8%, n=3,183), and hydrochlorothiazide(23.1%, n=1,805). 64.1% of the treated patients had uncontrolled HT based on the 24-hour ABPM values, 60.5% based on daytime values, and 67.1% based on nighttime values. Smoking (OR=1.931.46; 2.54), obesity (OR=1.661.39; 1.98), coffee consumption (OR=1.551.25; 1.91) and snoring (OR=1.441.20; 1.73) all significantly increased the risk of HT confirmed by 24-hour BP values in patients who received TCT containing a THZD. These predictive factors were also present in the other three groups. Conclusions: In contrast to current guidelines, the Hungarian ABPM Registry revealed that high proportion of treated hypertensive patients received monotherapy. On the other hand, in line with the guidelines, combination therapy is RAAS-blocker based in Hungary. The assessed lifestyle risk factors increase the risk of uncontrolled hypertension, thus their targeted treatment may be important to reduce cardiovascular morbidity and mortality.

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