Orthogonal Nanopores Cross-Validation for Multiplex Single-Molecule Profiling

Lin-Lin Zhang; Fan Gao; Wei Yi-he; Cheng‐Bing Zhong; Bingqing Xia; Liuqing Wen; Yi-Tao Long; Yi-Lun Ying

doi:10.1039/d6sc03524h

January 1, 2026Chemical ScienceOpen Access

Orthogonal Nanopores Cross-Validation for Multiplex Single-Molecule Profiling

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Key Points

This research aims to enhance biomolecule profiling methods for better health diagnostics.
Utilized orthogonal nanopore technology to analyze diverse biomolecules.
Conducted multiplex profiling for comprehensive molecular insights.
Assessed the impact of biomolecule diversity on profiling accuracy.
Achieved improved profiling accuracy across various biomolecule types.
Demonstrated effective distinction between biomolecules of different charges and sizes.
Indicated potential advancements in precision health outcomes.

Implication

Examines multiplex biomolecule profiling, indicating its utility in precision health.

Abstract

Multiplex biomolecule profiling provides comprehensive molecular insights essential for precision health diagnosis. However, the difficulty arises from the fundamental diversity of biomolecules. Their sizes, charges, structures, and chemical compositions differ...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc56bdee9eb8c0dce6ca4 https://doi.org/10.1039/d6sc03524h

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Orthogonal Nanopores Cross-Validation for Multiplex Single-Molecule Profiling

Key Points

Implication

Abstract

Discussion

Cite This Study

Orthogonal Nanopores Cross-Validation for Multiplex Single-Molecule Profiling

Key Points

Implication

Abstract

Discussion

Cite This Study

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