Key result
Tumor-related pericardial and myocardial infiltration mimics STEMI and leads to fatal cardiopulmonary failure.
Why the study?
Cardiac involvement in diffuse large B-cell lymphoma is rare and underrecognized, and concurrent pericardial and myocardial infiltration can mimic acute myocardial infarction on ECG, posing diagnostic challenges.
Case Report (n=1)
Lymphoma-associated cardio-infiltration can present as a STEMI-mimic, requiring early multidisciplinary evaluation and multimodal imaging to prevent unnecessary invasive interventions.
DLBCL cardiac infiltration may mimic STEMI; this case extends recognition but leaves open prospective validation of diagnostic strategies.
Background Cardiac involvement in diffuse large B-cell lymphoma (DLBCL) is rare and often underrecognized. Concurrent pericardial and myocardial infiltration can mimic acute myocardial infarction on electrocardiography, posing diagnostic challenges. Case presentation We present a 64-year-old female with biopsy-confirmed DLBCL who developed acute respiratory symptoms and electrocardiographic changes mimicking ST-elevation myocardial infarction (STEMI). Multimodal imaging revealed a large pericardial effusion, myocardial infiltration, and no obstructive coronary disease. Despite chemotherapy and supportive care, the patient succumbed to cardiopulmonary failure. Conclusions This case highlights a rare manifestation of lymphoma-associated cardio-infiltration presenting as STEMI-mimic. Early multidisciplinary evaluation is essential to differentiate pseudo-infarction syndromes and prevent unnecessary invasive interventions
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Burkitbayev et al. (2026) conducted a case report in Diffuse large B-cell lymphoma (DLBCL) with cardiac involvement (n=1). Tumor-related pericardial and myocardial infiltration was evaluated on Cardiopulmonary failure. Tumor-related pericardial and myocardial infiltration in a 64-year-old female with diffuse large B-cell lymphoma mimicked a STEMI and ultimately led to fatal cardiopulmonary failure.
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