Bone-targeted carbon dots coordinate osteo–angiogenic coupling and antibacterial defense to promote periodontal regeneration

Zansheng Huang; Tuo Wang; Junyu Ren; Yunfeng Wang; Wenxuan Zhang; Qing Li; Xuancheng Wei; Xinhua Shao; Jie Huang; Tonghao Jiang; Xiaohan Zhang; Xinrui Luan; Na Zhou; Shujian Zhang; Mengmeng Cao; Han Jin; Lei Wang; Ying Li

doi:10.1016/j.matdes.2026.116300

Key Points

To investigate the effects of bone-targeted carbon dots on osteo–angiogenic coupling and antibacterial defense in periodontal regeneration.
Evaluated carbon quantum dots with catalase-like and peroxidase-like activities for bone targeting.
Assessed antibacterial efficiency with membrane depolarization effects and coupled angiogenesis regulation.
Analyzed the involvement of the Wnt/β-catenin signaling pathway and bone homeostasis.
Bone-targeting rate was 75.57%.
Bactericidal efficiency exceeded 95% based on membrane depolarization-induced antibacterial activity.
Multifunctional carbon dots effectively regulated angiogenesis and the Wnt/β-catenin signaling pathway.

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Implication

Shows improved periodontal regeneration in bone-targeted carbon dots treatment, indicating significant therapeutic potential.

Abstract

• Carbon quantum dots with catalase-like and peroxidase-like nanozyme activities; bone-targeting rate: 75.57%. • Membrane depolarization–induced antibacterial activity; bactericidal efficiency exceeding 95%. • Multifunctional carbon quantum dots coupled with angiogenesis, regulation of the Wnt/β-catenin signaling pathway, balance of bone homeostasis.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc56bdee9eb8c0dce6ce8 https://doi.org/10.1016/j.matdes.2026.116300

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Bone-targeted carbon dots coordinate osteo–angiogenic coupling and antibacterial defense to promote periodontal regeneration

Key Points

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Cite This Study

Bone-targeted carbon dots coordinate osteo–angiogenic coupling and antibacterial defense to promote periodontal regeneration

Key Points

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Implication

Abstract

Discussion

Cite This Study

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