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June 3, 20260 citationsOpen Access

Anticancer Activity and Mechanistic Investigation of 4,5,6,7-Tetrahydrobenzo[b]thiophene...

Design, synthesis, anticancer activity, and mechanistic investigation of 4,5,6,7-tetrahydrobenzo b thiophene carboxamides as CDK-2 inhibitors: in vitro and in silico DFT and molecular docking study

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Authors

KAKurls E. AnwerRRRamadan M. RamadanENEman S. Nossier

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Overview

Randomized trial demonstrates anticancer effects in liver and breast cancer models, suggesting therapeutic potential.

Key Points

  • This research aims to design and evaluate 4,5,6,7-tetrahydrobenzo[b]thiophene carboxamides as potential CDK-2 inhibitors with anticancer properties.
  • Synthesized 4,5,6,7-tetrahydrobenzo[b]thiophene carboxamides using conventional heating and microwave-assisted techniques.
  • Assessed anticancer effects against HepG-2, MCF-7, and MDA-MB-231 carcinoma cell lines.
  • Conducted molecular docking to study binding interactions with cDK-2 receptor.
  • Compound 11 showed the highest cDK-2 inhibition, nearly threefold greater than roscovitine.
  • Significant cytotoxicity against HepG-2, MCF-7, and MDA-MB-231 cell lines observed with specific analogues.
  • MDA-MB-231 cell cycle was arrested at the G0/G1 phase, indicating apoptotic effects.
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Cite This Study

Anwer et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc56bdee9eb8c0dce6d8fhttps://doi.org/10.5445/ir/1000193699
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