Systematic review explores the role of non-pharmacological interventions in Rett syndrome, indicating gaps in utilization data.
Key Points
This review aims to evaluate the use of non-pharmacological supportive interventions in Rett syndrome care across various settings.
Systematic review following PRISMA guidelines and PICOST framework.
Examined literature from PubMed, Embase, and Cochrane, including gray literature.
Analyzed 28 studies focusing on non-pharmacological interventions in RTT, with a focus on ancillary services, assistive devices, surgical procedures, and assisted interventions.
Physical therapy utilization ranged from 24.4% to 100%, with pediatric patients using these services two to four times more than adults.
Wheelchair utilization reported up to 90% among patients examined in assistive device studies.
Surgical intervention rates for scoliosis ranged from 1.2% to 50% across the studies.