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June 3, 2026Journal of Hypertension0 citations

Association of Combined Hypertension and High Lipid Accumulation Product With the Risk of Incident Stroke Among Mongolian, China

AWAili WangSoochow University TXTan XuSoochow University YZYonghong ZhangSoochow University

Key Points

This research aims to evaluate the combined effects of hypertension and lipid accumulation product on stroke risk among Mongolians in China.
Cohort of 2589 Mongolians from 32 villages in Tongliao City, Inner Mongolia, China, followed from 2003 to 2012.
Data collected included cardiovascular risk factors, blood pressure, waist circumference, and triglycerides measurements.
Participants categorized by hypertensive status and lipid accumulation product levels, with stroke risk assessed using Cox proportional hazard models.
A total of 124 stroke cases were reported during follow-up among 2589 participants.
Higher lipid accumulation product correlated with an increased stroke risk (HR, 1.26; 95% CI, 1.02-2.39) compared to lower levels.
Hypertensives with high lipid accumulation product had the highest risk of stroke (adjusted HR, 4.10; 95% CI, 2.08-8.08) after controlling for other factors.

Abstract

Objective: Stroke is a major public health challenge in China. Hypertension is an important risk factor for stroke, blood lipids and obesity may play an important role in stroke development. This prospectively assess the joint effects of hypertension and Lipid accumulation product (LAP) on the risk of incident stroke among Mongolian population in China. Design and method: A cohort of 2589 Mongolians in 32 villages in Tongliao City, Inner Mongolia, China was investigated from 2003 to 2012. Data on cardiovascular risk factors were collected, blood pressure and waist circumference (WC) were measured, and blood lipid indicators including triglycerides (TG) were tested. The study outcome was defined as incident stroke. LAP was calculated by WC and TG concentration, LAP for men = WC (cm) - 65 × TG concentration (mmol/L), LAP for women = WC (cm) - 58 × TG concentration (mmol/L). High LAP was defined as LAP >= 16.83 (median). According to the hypertensive status and LAP, the participants were divided into following groups: normotensives/low LAP, normotensives/high LAP, hypertensives/low LAP, and hypertensives/high LAP. Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident stroke were calculated by Cox proportional hazard models. Results: During the follow-up, a total of 124 stroke patients occurred among 2589 Mongolians. The participants with higher LAP were associated with increased risk of incident stroke (HR, 1.26; 95% CI, 1.02-2.39) compared with those with lower LAP. Coexistence of hypertension and high LAP significantly increased risk of incident stroke. After adjusting for other cardiovascular risk factors, compared to normotensives with low LAP, adjusted HRs (95% CIs) for normotensives with high LAP, hypertensives with low LAP and hypertensives with high LAP were 1.78(0.82-3.83), 2.96 (1.52-5.78) and 4.10 (2.08-8.08), respectively. The hypertensives with high LAP had the highest risk of incident stroke. Conclusions: This study showed that hypertension and high LAP were associated with incidence of stroke, independently of other traditional risk factors. Hypertensives with high LAP had the highest risk of stroke among inner Mongolians.

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