Oleuropein and hydroxytyrosol enhance mitochondrial function and biogenesis in SH-SY5Y cells through estrogen-like mechanisms

Key Points

• The research aims to evaluate the effects of oleuropein and hydroxytyrosol on mitochondrial function and biogenesis in neuronal cells.
• Utilized SH-SY5Y neuronal cell line for experimentation
• Assessed metabolic efficiency and neuronal survival
• Investigated estrogen-like mechanisms involved in neuroprotection
• Oleuropein improved mitochondrial function with a significant increase in biogenesis
• Hydroxytyrosol enhanced neuronal survival rates against age-related decline
• Both compounds activated estrogen-like neuroprotective pathways, showing substantial promise for aging-related therapies