Integrated electronic health record databases provide an unprecedented opportunity to enhance knowledge of disease prediction, prevention, and management in real-world settings. The Precision Medicine (PMED) Registry is a cohort of approximately 2 million patients seen at NYU Langone Health inpatient and outpatient centers, capturing data generated during clinical care from January 1, 2010, to the present, with regular data updates. Data have been used for several research investigations, including international meta-analyses, validation of disease identification algorithms, local evaluation of risk tools, testing analytical pipelines for imaging data, and the investigation of novel correlates of established risk prediction models. Additionally, the assessment of local practice has provided insights into clinical practice patterns and aided quality improvement efforts to assess and promote the uptake of guideline-directed therapies at the system and provider level. This study illustrates how real-world integrated electronic health record data with multi-modal clinical information can be leveraged to support research in prediction, diagnosis, prevention, and treatment optimization across health systems.
Flaherty et al. (Mon,) studied this question.