Key result
Myosin IIB ablation in fibroblasts resulted in increased speed, decreased persistence, disorganized traction forces, and failure to respond to mechanical signals.
Population
Fibroblasts where myosin IIB has been ablated by gene disruption (myosin IIB null cells)
Comparison
Gene disruption of myosin IIB vs Control cells
Design
Preclinical
Authors
Loading...
Myosin IIB polarity role in fibroblasts is hypothesis-generating for remodeling; should not yet change clinical practice.
Myosin IIB is involved in directing cell movement by coordinating protrusive activities and stabilizing cell polarity, rather than simply propelling the cell.
Lo et al. (2003) studied Fibroblast migration. Myosin IIB ablation by gene disruption vs. Control cells was evaluated on Cell movement and mechanical characteristics. Myosin IIB ablation in fibroblasts resulted in increased speed, decreased persistence, disorganized traction forces, and failure to respond to mechanical signals.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: