Clinical profile of pancreatic adenocarcinoma

Objectives: Pancreatic adenocarcinoma (PAC) is an aggressive malignancy with poor survival, often diagnosed at advanced stages. This study evaluated the clinical features, tumour characteristics, and treatment patterns at a tertiary care hospital in South India. Material and Methods: A retrospective cross-sectional analysis was conducted on 205 PAC patients (2015–2022) at a tertiary care hospital in South India, Mangalore. Data on demographics, presentation, tumour characteristics, treatment modalities, and outcomes were collected from hospital records. Results: A total of 205 patients were included, with a median age of 60–70 years and a slight female predominance. The majority had periampullary tumours and advanced-stage disease at presentation. Kaplan–Meier analysis showed significantly better survival with adjuvant chemotherapy compared to palliative intent ( p = 0.003), while upfront surgery showed a trend toward improved survival without statistical significance. Conclusion: PAC in this cohort presented late with poor survival. Periampullary predominance, prognostic value of CA 19-9, and limited neoadjuvant use were noted. Multimodal therapy improved outcomes, underscoring the need for early detection and optimised treatment strategies.