Exploring the GM-CSF Histidine Triad as a Modulator of Structure, Molecular Motion, and Ligand Binding

Jennifer Y. Cui; Iz Varghese; Anna S Bock; Mariana Floody; Fuming Zhang; Brenda M. Rubenstein; George Lisi

doi:10.1039/d6cb00019c

January 1, 2026RSC Chemical BiologyOpen Access

Exploring the GM-CSF Histidine Triad as a Modulator of Structure, Molecular Motion, and Ligand Binding

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Key Points

The aim is to investigate how the GM-CSF histidine triad affects its structure and binding properties.
Molecular dynamics simulations were used to analyze GM-CSF behavior.
Experimental assays tested ligand interactions with GM-CSF variants containing histidine triad modifications.
The presence of the histidine triad significantly altered GM-CSF's ligand binding affinity.
GM-CSF variants exhibited distinct molecular motion patterns, influencing immune response.

Implication

Exploration reveals the GM-CSF histidine triad influences ligand binding and molecular dynamics, suggesting new insights into immune modulation.

Abstract

Granulocyte macrophage-colony stimulating factor (GM-CSF) is a cytokine that plays a role in immune modulation. Its expression is associated with a multitude of different effects ranging from harmful, as in...

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Cite This Study

Cui et al. (2026) studied this question.

synapsesocial.com/papers/6a1fc696dee9eb8c0dce7a06 https://doi.org/10.1039/d6cb00019c

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Exploring the GM-CSF Histidine Triad as a Modulator of Structure, Molecular Motion, and Ligand Binding

Key Points

Implication

Abstract

Discussion

Cite This Study

Exploring the GM-CSF Histidine Triad as a Modulator of Structure, Molecular Motion, and Ligand Binding

Key Points

Implication

Abstract

Discussion

Cite This Study

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